Do old urinary biomarkers have a place in the new definition of hepatorenal syndrome in the Egyptian cirrhotic patients? A single-center experience

Abstract Background Hepatorenal syndrome is still a diagnosis of exclusion despite new classification. Aims To validate the accuracy urinary neutrophil gelatinase-associated lipocalin, interleukin-18, and kidney injury molecule-1 in diagnostic criteria hepatorenal Egyptian patients with hepatitis C virus-related liver cirrhosis using serum creatinine as gold standard test for acute injury. Methods One-hundred twenty cirrhotic ascites were recruited divided into two groups depending on presence or absence renal impairment, 40 age- sex-matched without used controls participated study. Urinary biomarkers measured compared conventional to assess function (serum creatinine, estimated glomerular filtration rate). Results The mean statistically significantly higher found be helpful early detection cutoff values 125 ng/ml, 34.8 pg/ml, 3.1 respectively. Conclusions levels are complicated by HRS-AKI definition HRS, but IL-18 has lower sensitivity specificity prediction NGAL KIM-1.